Study Finds Psilocybin Improves Neural, Cognitive Flexibility in Patients with Depression

A new study has found that psilocybin-assisted psychotherapy increases neural and cognitive flexibility in patients suffering from major depressive disorder. Psilocybin is the active compound found in hallucinogenic mushrooms. Research has found that the component has clinically substantial and long-lasting effects on mood and personality when used in conjunction with psychotherapy.

The study was published in “Translational Psychiatry,” with researchers suggesting that psychedelic-induced increases in neural flexibility don’t always translate into cognitive improvements.

The study’s authors were focused on assessing the effects of psilocybin on neural flexibility, which refers to variability in brain connectivity and activity, and cognitive flexibility, which refers to the ability to adapt one’s thinking and behavior with regards to their environment.

Manoj Doss, who is a postdoctoral researcher at the Johns Hopkins University’s Center for Psychedelic and Consciousness Research, stated that various mental health conditions had impairments in cognitive flexibility, explaining that based on data from animal models, psychedelic substances had shown improved cognitive flexibility.

For their study, the researchers assessed data from a prior study, whch had found that psilocybin-assisted therapy decreased symptoms of depression. They administered psilocybin to their participants at different intervals, after which each of the participants went through 18 sessions of psychotherapy. In addition, each participant had brain scans taken four weeks before their initial psilocybin session and a week after their second psilocybin-assisted therapy session.

They also completed the Penn Conditional Exclusion Test, which is a measure of cognitive flexibility. The researchers discovered that one week after the psychedelic substance was first administered, dynamic functional connectivity between regions in the brain that support cognitive flexibility increased.

In their report, the researchers stated that it was possible that improvements in neural and cognitive flexibility could open a plasticity window through which enhancements could be facilitated. Researchers also found a complex relationship between neural flexibility and cognitive flexibility, noting that increases in neural flexibility were linked to fewer improvements in cognitive flexibility. In an interview, Doss noted that while neural flexibility supported cognitive flexibility, too much of it could have negative effects.

The researchers highlighted that the study had some limitations, which includes its small sample and its open-label design. Doss added that the findings probably wouldn’t hold up in a different mental health condition or in a sample that was psychiatrically healthy.

Other researchers who were part of the study include Frederick S. Barrett, Roland R. Griffiths, Peter B. Barker, James J. Pekar, Gwenn S. Smith, Patrick H. Finan, Alan K. Davis, Nathan D. Sepeda, Monica D. Rosenberg and Michael Považan.

Studies have pointed out that psilocybin has immense therapeutic potential. Therefore, it is no surprise that many companies, including Tryp Therapeutics Inc. (CSE: TRYP) (OTCQB: TRYPF), are in various stages of developing and commercializing medicines from this psychedelic and others.

NOTE TO INVESTORS: The latest news and updates relating to Tryp Therapeutics Inc. (CSE: TRYP) (OTCQB: TRYPF) are available in the company’s newsroom at https://ibn.fm/TRYPF

About PsychedelicNewsWire

PsychedelicNewsWire (PNW) is a specialized content distribution company that (1) aggregates and distributes news and information on the latest developments in all aspects and advances of psychedelics and their use, (2) creates PsychedelicNewsBreaks designed to quickly update investors on important industry news, (3) leverages a team of expert editors to enhance press releases for maximum impact, (4) assists companies with the management and optimization of social media across a range of platforms, and (5) delivers unparalleled corporate communication solutions. PNW stays abreast of the latest information and has established a reputation as the go to source for coverage of psychedelics, therapeutics and emerging market opportunities. Our team of seasoned journalists has a proven track record of helping both public and private companies gain traction with a wide audience of investors, consumers, media outlets and the general public by leveraging our expansive dissemination network of more than 5,000 key syndication outlets. PNW is committed to delivering improved visibility and brand recognition to companies operating in the emerging markets of psychedelics.

To receive instant SMS alerts, text “Groovy” to 21000 (U.S. Mobile Phones Only)

For more information please visit https://www.PsychedelicNewsWire.com

Please see full terms of use and disclaimers on the PsychedelicNewsWire website applicable to all content provided by PNW, wherever published or re-published: https://www.PsychedelicNewsWire.com/Disclaimer

Do you have questions or are you interested in working with PNW? Ask our Editor

PsychedelicNewsWire (PNW)
San Francisco, California
www.PsychedelicNewsWire.com
415.949.5050 Office
Editor@PsychedelicWire.com

PsychedelicNewsWire is part of the InvestorBrandNetwork.

Archives

Select A Month

PsychedelicNewsWire Currently Accepts

Bitcoin

Bitcoin

Bitcoin Cash

Bitcoin Cash

Doge Coin

Dogecoin

Ethereum

Ethereum

Litecoin

Litecoin

USD Coin

USD Coin

Contact us: 415.949.5050